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Every subject includes basic engineering and application to biotechnology & medical engineering, simultaneously.
1) Collaboration with Medical University including the research project "Medical Engineering Research Center" develops interdisciplinary study courses between Biology, Medicine and Engineering.
3) Subjects also include Basic Engineering (mechanics, electronics, material science) for industry.
Special Reserch on Biomedical Engineering
Consideration on mechanics mainly in the circulatory system.
Application to design of artificial organs.
1. Interdisciplinary field of study, Biomeasurement, Bioelectronics
2. Biomaterials (Hemolysis)
3. Biorheology (Blood circulation)
4. Transport phenomenon, Biochemical Engineering (Oxygenator, Dialyzer)
5. Biomechanics, Biotribology (Joint prosthesis), Cellular mechanics
(Core Courses)
Seminar for Mechanical Engineering
Experiments on Mechanical Engineering
Biomedical Engineering Seminar
Bachelor Thesis
Bio-mechanics
(Common Courses)
Internship
The lecture is introduction for students, who are interested in biological and medical equipment, to learn basic mechanical engineering.
The lecture is also introduction for students, who are studying engineering, to learn application of engineering to biological and medical equipment.
The lecture is trying to analyze human body in comparison with the machine, to consider cooperation between an organ and a machine in relation to medical devices for human,
to study basic mechanical engineering to analyze a living body.
In recent years, several devices like artificial organs have been developed to substitute biological organs.
To design the artificial organs, the biological function should be defined. In addition, quantitative specification is necessary for design of machine.
The quantitative information about function of organs, however, is not enough for design of artificial organs.
Data on normal organs are not enough compared with those on injured organs. Trial of the artificial organ helps analysis of biological function.
The biological system may inspire an idea for the new machine.
In modern medical practice, various devices have been introduced.
If you do not understand both the characteristics of devices and that of organs at the same time, however, there is a risk that devices are not properly used to the living body.
Considering co-cooperation between devices and organs improves the devices to be applied to the living body.
The knowledge of mechanical engineering is available not only for the medical instrumentation, but also for biological understanding. The lecture may introduce readers to advanced learning for physiology and mechanical engineering.
Contents
Chap. 1: Organism and Machine
1.1 Character of organism and machine
1.2 Interdisciplinary field of study
Chap. 2: Unit and Measurement
2.1 Unit and significant digit
2.1.1 Unit
2.1.2 Significant digit
2.2 Measurement
2.2.1 Resolution
2.2.2 Measurement system
2.2.3 Alternating component
2.2.4 Non-invasive
2.2.5 Non-linear and equilibrium
2.2.6 Noise and statistics
Chap. 3: Materials
3.1 Deformation
3.1.1 Classification of deformation
3.1.2 Cutting and fixation of specimen
3.1.3 Setting of origin and range of measurement
3.1.4 Stress-strain diagram
3.1.5 Elastic region and plastic region
3.1.6 Sphere
3.1.7 Bending
3.2 Properties and Destruction of Material
3.2.1 Fatigue fracture
3.2.2 Crystal and lattice defect
3.2.3 Stress concentration
3.2.4 Composite material and environment
Chap. 4: Flow
4.1 Fluid and solid
4.1.1 Fluid and pressure
4.1.2 Elasticity and viscosity
4.1.3 Viscoelasticity
4.2 Resistance of flow and distribution of velocity
4.2.1 Resistance of flow
4.2.2 Hagen-Poiseuille Flow
4.2.3 Requirement for Hagen-Poiseuille Flow
4.2.4 Couette Flow
4.2.5 Flow between parallel walls
4.2.6 Secondary flow
4.3 Steady flow and non-steady flow
4.3.1 Pulsatile flow
4.3.2 Laminar flow and turbulent flow
Chap. 5: Energy
5.1 State of substance
5.1.1 Temperature
5.1.2 Hydrogen ion concentration index
5.1.3 Heat
5.1.4 Phase transformation
5.2 Energy conversion
5.2.1 Form of energy
5.2.2 Conversion efficiency
5.3 Substance transportation
5.3.1 Permeability through membrane
5.3.2 Osmotic pressure
Chap. 6: Movement
6.1 Balance among forces and control of movement
6.1.1 Balance among forces
6.1.2 Description of movement
6.2 Lubrication and wear
6.2.1 Machine elements and systems
6.2.2 Coefficient of friction
6.2.3 Contact
6.2.4 Surface tension and hydrophilic property
6.2.5 Wear
6.2.6 Lubrication
Chap. 7: Designing and Machining
7.1 Design
7.1.1 Specifications
7.1.2 Draft
7.1.3 Surface roughness
7.2 Machining
7.2.1 Type of machining
7.2.2 Finishing and biological reaction
7.2.3 Assembly
References
1) S. Hashimoto: gCross-cultural communication training for students in multidisciplinary research area of biomedical engineeringh, Journal of Systemics, Cybernetics and Informatics, 12, 5, pp. 43-48 (2014).
2) S. Hashimoto: gRole of bridge-curriculum for multidisciplinary courses: application to biomedical engineeringh, Journal of Communication and Computer, 8, 12, pp. 1117-1122 (2011).
3) S. Hashimoto: gIntroduction to Biomedical Measurement Engineeringh, Corona Publishing Co., Ltd. (2000). In Japanese
4) S. Hashimoto: gJSME Mechanical Engineersf Handbook, Ā8 BioengineeringCChap 5, Section 3, Biomeasurementh, pp. 191-200, The Japan Society of Mechanical Engineers (2007). In Japanese
5) S. Hashimoto: gJSME Mechanical Engineersf Handbook, Ā5 Measurement Engineering, Chap 5, Section 6.4, Bioengineeringh, pp. 109-113, The Japan Society of Mechanical Engineers (2007). In Japanese
6) S. Hashimoto, et al.: gWave-form analysis of electrocardiograph with spectrum for screening testh, Proc. 4th World Congress of Biomechanics, CD-ROM, (2002).
7) S. Hashimoto and H. Otani: gMeasurement of mechatronic property of biological gel with micro-vibrating electrode at ultrasonic frequencyh, Journal of Systemics, Cybernetics and Informatics, 6, 5, pp. 93-98 (2008).
8) S. Hashimoto, et al.: gMeasurement of cell distribution in organs with Lissajous of impedanceh, Proc. 5th World Multiconference on Systemics, Cybernetics and Informatics, 10, pp. 443-447 (2001).
9) K. Matsuyoshi, et al.: gOptical measurement system for pH in medium around contracting myotubes in vitroh, Proc. 14th World Multi-Conference on Systemics Cybernetics and Informatics, 2, pp. 275-279 (2010).
10) S. Hashimoto, et al.: gMeasurement of cyclic micro-deformation of arterial wall with pulsatile flowh, Progress in Biomedical Optics and Imaging, 3, 1, pp. 456-463 (2002).
11) S. Hashimoto, et al.: gMeasurement of periodical contraction of cultured muscle tube with laserh, Journal of Systemics, Cybernetics and Informatics, 7, 3, pp. 51-55 (2009).
12) S. Hashimoto, et al.: gMeasurement system for body temperature during transition period of hibernating animalh, Proc. 8th World Multiconference on Systemics Cybernetics and Informatics, 7, pp.156-159 (2004).
13) S. Hashimoto, et al.: gApplication of inductively coupled wireless radio frequency probe to knee joint in magnetic resonance imageh, Journal of Systemics, Cybernetics and Informatics, 7, 5, pp. 6-10 (2009).
14) S. Hashimoto, et al.: gResponses of cells to flow in vitroh, Journal of Systemics, Cybernetics and Informatics, 11, 5, pp. 20-27 (2013).
15) S. Hashimoto: gErythrocyte destruction under periodically fluctuating shear rate; comparative study with constant shear rateh, Artificial Organs, 13, pp. 458-463 (1989).
16) S. Hashimoto and M. Okada: gOrientation of cells cultured in vortex flow with swinging plate in vitroh, Journal of Systemics, Cybernetics and Informatics, 9, 3, pp. 1-7 (2011).
17) S. Hashimoto and Tianyuan WANG: gMeasurement of pressure between upper airway tract and laryngoscope blade during orotracheal intubation with film of microcapsulesh, Journal of Systemics, Cybernetics and Informatics, 12, 2, pp. 81-85 (2014).
18) T. Sahara, et al.: gRadio frequency probe for improvement of signal to noise ratio in magnetic resonance image with inductively coupled wireless coilh, Proc. 12th World Multi-Conference on Systemics Cybernetics and Informatics, 2, pp. 115-119 (2008).
19) T. Iwagawa, et al.: gEffect of electric stimulation on penetration of molecules into agarose gelh, Proc. 14th World Multi-Conference on Systemics Cybernetics and Informatics, 2, pp. 255-260 (2010).
20) S. Hashimoto and N. Kawano: gA newly designed flow-regulating device in shunt therapy of hydrocephalush, Artificial Organs, 13, 5, pp. 483-485 (1989).
21) S. Hashimoto, et al.: gDesign of venous cannula entrance for pulsatile pump considering collapse of vesselsh, Artificial Organs, 12, 1, pp. 245-248 (1983).
22) National Institute of Natural Sciences, National Astronomical Observatory of Japan: Chronological Scientific Tables, p. 444, p458, Maruzen Publishing CO., Ltd (1996).
23) S. Hashimoto, et al.: gMeasurement of mechatronic property of blood during coagulation with micro-vibrating electrodeh, Proc. 10th World Multiconference on Systemics Cybernetics and Informatics, 4, pp. 177-180 (2006).
24) S. Hashimoto: gIntroduction to Biosystems Engineeringh, Tokyo Denki University Press (1996). In Japanese
25) S. Hashimoto, et al.: gEffect of shear rate on clot growth at foreign surfacesh, Artificial Organs, 9, 4, pp. 345-350 (1985)
26) S. Hashimoto, et al.: gEffect of aging on deformability of erythrocytes in shear flowh, Journal of Systemics, Cybernetics and Informatics, 3, 1, pp. 90-93 (2005).
27) F. Sato, et al.: gResponses of cells to fluid shear stress in vitroh, Proc. 16th World Multi-Conference on Systemics Cybernetics and Informatics, 2, pp. 97-102 (2012).
28) S. Hashimoto, et al.: gDesign of flow path of centrifugal pump for prevention of clot growthh, Artificial Organs, 17, 3, pp. 879-882 (1988).
29) S. Hashimoto: gClot growth under periodically fluctuating shear rateh, Biorheology, 31, pp. 521-532 (1994).
30) S. Hashimoto, et al.: gEffect of pulsatile shear flow on migration of endothelial cells cultured on tubeh, Proc. 6th World Multiconference on Systemics Cybernetics and Informatics, 2, pp. 296-300 (2002).
31) S. Hashimoto, et al.: gClot formation in artificial hearth, Kitasato MedicineC17, 2, pp. 87-91 (1987).
32) S. Hashimoto, et al.: gEffect of magnetic field on adhesion of muscle cells to culture plateg, Journal of Systemics, Cybernetics and Informatics, 11, 4, pp. 7-12 (2013).
33) Y. Sakatani, et al.: gEffect of static magnetic field on muscle cells in vitroh, Proc. 14th World Multi-Conference on Systemics Cybernetics and Informatics, 2, pp. 280-284 (2010).
34) C. Miyamoto, et al.: gEffect of magnetic field at low frequency on cells arrangementh, Proc. 7th World Multiconference on Systemics Cybernetics and Informatics, 8, pp. 62-66 (2003).
35) S. Hashimoto, et al., gEffect of pulsatile electric field on cultured muscle cells in vitroh, Journal of Systemics, Cybernetics and Informatics, 10, 1, pp. 1-6 (2012).
36) S. Hashimoto, et al.: gA newly designed pneumatic-pulse-pump-membrane oxygenatorh, Artificial Organs, 14, S1, pp. 181-185 (1990).
37) S. Hashimoto and H. Moriya: gEffect of right ventricular bypass peak flow-rate on intrapulmonary shunt ratioh, Artificial Organs, 12, 1, pp. 67-77 (1988).
38) S. Hashimoto, et al.: gFlow control by piston-bellows type of artificial hearth, Kitasato Medicine, 15, 4, pp. 245-249 (1985).
39) S. Hashimoto, et al.: gHemolysis in artificial hearth, Kitasato Medicine, 17, 5, pp. 415-419 (1987).
40) S. Motoda, et al.: gEffect of excess gravitational force on cultured myotubes in vitroh, Proc. 15th World Multi-Conference on Systemics Cybernetics and Informatics, 2, pp. 118-123 (2011).
41) S. Hashimoto, et al.: gApplication of quartz crystal oscillator to atmospheric molecule sensorh, Proc. International Federation for Medical and Biological Engineering, 3, 1, pp. 304-305 (2002).
42) S. Hashimoto, et al.: gFlow pattern of piston-bellows type of artificial hearth, Artificial Organs, 10, 6, pp. 1229-1232 (1981).
43) S. Hashimoto, et al.: gEffect of segmented polyurethane coating on thrombus regulated with pulsatile shear flowh, Proc. 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, CD-ROM, 4 pages (2001).
44) S. Hashimoto: gWear of heart valve prosthesish, Japanese Journal of Tribology, 35, 12, pp. 1367-1373 (1990).
45) S. Hashimoto, et al.: gSimulation of cell group formation regulated by coordination number, cell cycle and duplication frequencyh, Journal of Systemics, Cybernetics and Informatics, 11, 4, pp. 29-33 (2013).
46) H. Hino, S. Hashimoto, and F. Sato: gEffect of micro ridges on orientation of cultured cellh, Journal of Systemics, Cybernetics and Informatics, 12, 3, pp. 47-53 (2014).
47) S. Hashimoto: gDetect of sublethal damage with cyclic deformation of erythrocyte in shear flowh, Journal of Systemics, Cybernetics and Informatics, 12, 3, pp. 41-46 (2014).
48) Y. Takahashi, S. Hashimoto, et al.: gMicro groove for trapping of flowing cellh, Journal of Systemics, Cybernetics and Informatics, 13, 3, pp. 1-8 (2015).
49) H. Hino, S. Hashimoto, et al.: gBehavior of cell on vibrating micro ridgesh, Journal of Systemics, Cybernetics and Informatics, 13, 3, pp. 9-16 (2015).
Answers to Questions
Index
Report:
Design a new device, which acts as a part of the human body. Describe the specifications, including original drawings and numerical description within one page of A4 paper. The description includes following items: problem to be solved, devised methods, background, reference, expected results and contribution to the society. Write the student number and name at the top of the page. Write references at the end of the page. If the reference is Uniform Resource Locator (URL), reference date should be written. Send the report as an attachment to an e-mail in PDF format until the end of February 2021.